Institution guide

Introduction to the Laboratories

Professor Hiroyuki Kugoh

Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University
Division of Molecular Genetics and Biofunction, Department of Biomedical Science
Division of Molecular and Cell Genetics, Department of Molecular and Cellular Biology,
School of Life Sciences, Faculty of Medicine (concurrent post)
Director of the Chromosome Engineering Research Center (concurrent post)

From identifying genes involved in cancer and cellular senescence to building the basic foundation for biomedical resources that support drug discovery

We have already confirmed the presence of numerous genes that control cancer and cellular senescence in various chromosomes through research using the world’s most advanced chromosome engineering technology to individually transfer normal human chromosome into cancer cells. On the other hand, recently, high-performance transcriptome analysis has become possible with the rapid development of next-generation sequencing technology. We are now attempting to implement the next-generation sequencing analysis technology and to identify unknown gene clusters related to cancer and cellular senescence, in order to take our past results to the next level. Further studies aimed at identification of genes that control tumor, aging will be required in order to clarify signaling pathways of cancer development, and eventually lead to building the basic foundation for biomedical resources that support drug discovery.

Associate Professor Yasuhiro Kazuki

Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University
Division of Molecular Genetics and Biofunction, Department of Biomedical Science
Division of Molecular and Cell genetics, Department of Molecular and Cellular Biology,
School of Life Sciences, Faculty of Medicine (concurrent post)
Biomodel Animal Development Division, Chromosome Engineering Research Center (concurrent post)

Using chromosome engineering technology to pursue exciting research

Chromosome engineering technology holds limitless possibilities. While carrying out our daily research, our group’s mission is to obtain the world’s most advanced research results using chromosome engineering technology and to apply those results to pharmaceutical development, linking them to actual health care practices. Within that scope, I hope to create biomedical resources that can be used to develop business. While this endeavor is extremely difficult, I will never forget how moved I felt when our research team achieved goals such as restoring genetic defects in muscular dystrophy with iPS cells using a [human artificial chromosome vector] we developed or completing a human CYP3A containing mouse and confirming that this mouse had the same capacity to metabolize drugs as humans. How about joining us in our exciting research?

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